Diagnostic value of urine microprotein combined test for hypertensive renal damage
10.3760/cma.j.issn.1008-6706.2019.05.007
- VernacularTitle:尿微量蛋白联合检测对高血压肾损害的诊断价值
- Author:
Miao CHEN
1
Author Information
1. 宁波市奉化区人民医院检验科 315500
- Keywords:
Hypertension;
Renal insufficiency;
chronic;
Albuminuria;
Diagnosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(5):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of combined detection of urinary microprotein in the diagnosis of hypertensive renal damage.Methods From January 2015 to October 2017,in the People's Hospital of Fenghua District,60 patients with hypertension(hypertension group) and 60 patients with hypertension nephropathy (hypertensive nephropathy group) were selected,and 60 cases who underwent physical examination at the same time were selected as control group.Urinary microalbumin,urinary α1-microglobulin,urinary β2-microglobulin were detected in three groups.The correlation between urinary microalbumin,urinary α1-microglobulin,urinary β2-microglobulin and hypertensive renal damage was analyzed.The diagnostic sensitivity,specificity and accuracy of the three indicators for hypertensive renal damage were calculated.Results The levels of urinary microalbumin,α1-microglobulin and β2-microglobulin in the hypertensive nephropathy group were (13.96 ± 4.23) mg/L,(16.94 ± 5.17) mg/L and (1.04 ± 0.58) mg/L,respectively,which in the hypertension group were (9.25 ± 2.81) mg/L,(11.29 ± 3.58) mg/L and (0.56 ± 0.39)mg/L,respectively,which in the control group were (6.43 ± 2.16)mg/L,(7.65 ± 2.47)mg/L and (0.27 ± 0.18) mg/L,respectively,the differences among the three groups were statistically significant (F =11.913,10.534,10.925,all P ＜ 0.05).By Pearson correlation coefficient analysis,it was found that urinary microalbumin,urinary α1-microglobulin and urinary β2-microglobulin levels were positively correlated with the occurrence of renal damage in hypertension (r =0.794,0.803,0.765,all P ＜ 0.05).The sensitivity,specificity and accuracy of urinary microalbumin,urinary o1-microglobulin and urinary β2-microglobulin in the diagnosis of hypertensive renal damage hadno statistically significant differences (x2 =0.379,1.515,0.189,all P ＞0.05).Conclusion Urinary microalbumin,urinary α1-microglobulin and urinary β2-microglobulin are sensitive markers of early renal damage in patients with hypertension,and can be used as markers for early diagnosis of hypertensive renal damage.
