Recent advances in regulatory effects of microRNA in thyroid-associated ophthalmopathy
10.3760/cma.j.issn.2095-0160.2019.05.015
- VernacularTitle:微小RNA在甲状腺相关性眼病发病过程中的调控作用
- Author:
Lan CHEN
1
Author Information
1. 广西医科大学第一附属医院眼科
- Keywords:
Micro RNA;
Thyroid-associated ophthalmopathy;
Regulatory effect;
Recent advances
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(5):396-400
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are endogenous,single-stranded,noncoding RNAs with 18 to 24 nucleotides in length.miRNAs play important regulatory roles by targeting mRNAs for cleavage or translational repression.Thus,they negatively regulate gene expression at the post-transcriptional level.miRNA can degrade target mRNA or inhibit the translational level of their target mRNAs,which in turn affects cell differentiation,proliferation and apoptosis,and thus plays an important role in the regulation in the occurrence of diseases and the development of the organism.Recent studies have shown that miRNA also plays an important regulatory role in the development of thyroid-associated ophthalmopathy (TAO).This article reviewed the regulatory effect of miRNA in the development of TAO,providing a new insight in the pathogenesis and treatment of TAO.
