Research progress on single nucleotide polymorphisms of genes associated with diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2019.05.014
- VernacularTitle:糖尿病视网膜病变相关基因单核苷酸多态性
- Author:
Junlin HAN
1
Author Information
1. 天津医科大学眼科临床学院 天津市眼科医院 天津市眼科学与视觉科学重点实验室 天津市眼科研究所 300020
- Keywords:
Diabetic retinopathy;
Gene;
Single nucleotide polymorphism;
Type 2 diabetes
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(5):390-395
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is the common cause of irreversible vision loss in adults during working age,accounting for 4.8％ of global blindness.With the progress of disease,most patients with diabetes mellitus will eventually lead to DR.Epidemiological studies have shown that the severity of DR is closely related to blood glucose levels and duration of diabetes,but there is growing evidence that genetic factors play an important role in the development and progression of DR.As the relationship between genetic polymorphism and DR constantly deepen,dozens of DR-related genes and genetic variations have been screened out from the PubMed Network Human Mendel Genetics Online till March 1,2018,including vascular endothelial growth factor,aldose reductase,receptor for advanced glycation end products,mitochondrial thioredoxin antioxidant system,monocyte chemoattractant protein-1,interleukin (IL)-6,IL-8 and other genes,some genetic polymorphisms have been identified as a genetic risk factor for DR in diabetic patients.The progress of genetic polymorphisms closely related to DR was summarized.
