Research progress of nucleotide-binding oligomerzation domain like receptors 3 inflammasome in age-related macular degeneration
10.3760/cma.j.issn.2095-0160.2019.01.017
- VernacularTitle:核苷酸结合寡聚化结构域样受体3炎症小体在年龄相关性黄斑变性中的研究进展
- Author:
Mengsha SUN
1
Author Information
1. 上海交通大学附属第一人民医院眼科 上海市眼底病重点实验室 200080
- Keywords:
Age-related macular degeneration;
Inflammation;
Nucleotide-binding oligomerzation domain like receptors 3;
Inflammasome
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disease characterized by the deterioration of the macula resulting in impaired visual acuity,which could probably cause irreversible vision loss.The pathogenesis of AMD is not clear yet though it has been found related to inflammation.As an important component of innate immunity,nucleotide-binding oligomerzation domain like receptors 3 (NLRP3)inflammasome may play a role in AMD.This article reviewed the progress in the studies of the role of NLRP3 inflammasome in AMD via discussing the activation mechanism of it,which may provide a novel treatment strategy of AMD by targeting NLRP3 inflammasome.
