Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy after In Vitro Fertilization and Embryo Transfer
10.3349/ymj.2019.60.3.285
- Author:
Sung Woo KIM
1
;
Yong Jin KIM
;
Jung Ho SHIN
;
Hoon KIM
;
Seung Yup KU
;
Chang Suk SUH
;
Seok Hyun KIM
;
Young Min CHOI
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. jyhsyk@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Anti-Müllerian hormone;
follicle stimulating hormone;
ectopic pregnancy;
in vitro fertilization;
ovarian stimulation
- MeSH:
Chorionic Gonadotropin;
Embryo Transfer;
Embryonic Structures;
Female;
Fertilization in Vitro;
Follicle Stimulating Hormone;
Humans;
In Vitro Techniques;
Incidence;
Infertility;
Observational Study;
Oocyte Retrieval;
Oocytes;
Ovarian Reserve;
Ovulation Induction;
Pregnancy;
Pregnancy Outcome;
Pregnancy, Ectopic;
Pregnant Women
- From:Yonsei Medical Journal
2019;60(3):285-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. MATERIALS AND METHODS: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. RESULTS: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p=0.012) analysis, DOR was associated with a higher risk of EP. CONCLUSION: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.
