Optimal First-line Eradication Regimens for Helicobacter pylori Infection in Patients with Clarithromycin Resistance: A Pilot Study
10.7704/kjhugr.2018.18.4.242
- Author:
Min Woo SEO
1
;
Yeon Jeong JEONG
;
Joon Sung KIM
;
Byung Wook KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. kijoons@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Clarithromycin;
Helicobacter pylori;
Metronidazole;
Microbial drug resistance
- MeSH:
Bismuth;
Breath Tests;
Clarithromycin;
Helicobacter pylori;
Helicobacter;
Humans;
Korea;
Metronidazole;
Pilot Projects
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2018;18(4):242-246
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Helicobacter pylori eradication rates using first-line treatment have decreased due to clarithromycin resistance. The aim of this study was to investigate optimal eradication regimens for patients with clarithromycin resistance in Korea. MATERIALS AND METHODS: A total of 72 patients with confirmed clarithromycin resistance were enrolled from August 2015 to July 2017. Patients were randomized to a 7-day bismuth quadruple therapy (BQT) regimen or a 7-day metronidazole triple therapy (MTT) regimen. Eradication was confirmed using the 13C-urea breath test. RESULTS: There were no differences in baseline characteristics between the groups. Intention-to-treat eradication rates were 77.8% for the BQT group and 66.7% for the MTT group (P=0.293). Per protocol eradication rates were 87.5% for the BQT group and 77.4% for the MTT group (P=0.292). Adverse events were more frequent in the BQT group. CONCLUSIONS: Eradication rates using MTT were comparable to those using BQT, and adverse events were less frequent in the MTT group. Thus, MTT may be considered as a first-line regimen for patients with clarithromycin resistance. Since this was a pilot study, a study with a large group is required.
