Helicobacter pylori Eradication in Patients with an Iatrogenic Ulcer after Endoscopic Resection and Peptic Ulcer
10.7704/kjhugr.2018.18.1.30
- Author:
Seol SO
1
;
Ji Yong AHN
;
Hee Kyong NA
;
Kee Wook JUNG
;
Jeong Hoon LEE
;
Do Hoon KIM
;
Kee Don CHOI
;
Ho June SONG
;
Gin Hyug LEE
;
Hwoon Yong JUNG
Author Information
1. Department of Gastroenterology, Asan Medical Center, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, Seoul, Korea. ji110@hanmail.net
- Publication Type:Original Article
- Keywords:
Endoscopic mucosal resection;
Endoscopic submucosal dissection;
Helicobacter pylori;
Peptic ulcer
- MeSH:
Compliance;
Helicobacter pylori;
Helicobacter;
Humans;
Peptic Ulcer;
Retrospective Studies;
Ulcer
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2018;18(1):30-37
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: We aimed to compare the outcomes and timing of Helicobacter pylori eradication in patients with iatrogenic and peptic ulcers. MATERIALS AND METHODS: This was a retrospective study of 183 patients treated between 2012 and 2015 with 7-day standard triple therapy after endoscopic resection (ER). The patients were enrolled as the iatrogenic ulcer group and assigned to an early treatment group (n=139, H. pylori eradication initiated 2 days after ER) and a late treatment group (n=44, 8 weeks after ER). During the same period, 152 patients with peptic ulcer were assigned to the peptic ulcer group. RESULTS: Successful H. pylori eradication was achieved in 141 patients (77.0%) in the iatrogenic ulcer group and 114 (75.0%) in the peptic ulcer group (P=0.661). Among the ER patients, the eradication rate was 79.9% (n=111) in the early treatment group and 68.2% (n=30) in the late treatment group (P=0.109). The adverse event rate was significantly higher in the peptic ulcer group than in the iatrogenic ulcer group (13.8% vs. 4.9%, P=0.005). Compliance and adverse events did not significantly differ between the early and late treatment groups. CONCLUSIONS: In iatrogenic ulcer, H. pylori eradication can be performed with a relatively lower adverse event rate, regardless of treatment timing, than that in peptic ulcer.
