Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers
10.11106/ijt.2018.11.1.41
- Author:
In Hye CHAE
1
;
Eun Kyung KIM
;
Hee Jung MOON
;
Jung Hyun YOON
;
Vivian Y. PARK
;
Hye Sun LEE
;
Jieun MOON
;
Jin Young KWAK
Author Information
1. Department of Radiology, National Cancer Center, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Lymphocyte;
Lymph node metastasis;
Neutrophil;
Recurrence;
Papillary thyroid carcinoma
- MeSH:
Humans;
Iodine;
Logistic Models;
Lymph Nodes;
Lymphocytes;
Neoplasm Metastasis;
Neutrophils;
Recurrence;
Retrospective Studies;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy
- From:International Journal of Thyroidology
2018;11(1):41-48
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The present study investigated the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). MATERIALS AND METHODS: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. RESULTS: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. CONCLUSION: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.
