Transforming Growth Factor-beta1 Promoter Polymorphism in Childhood Asthma.
- Author:
Jun Young PARK
1
;
Tae Won SONG
;
Kyung Won KIM
;
Eun Soo KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics and Institute of Allergy, Severance Children's Hospital, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kekim@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Asthma;
Transforming growth factor-beta1;
Promoter;
Polymorphism
- MeSH:
Alleles;
Asthma*;
Child;
Eosinophil Cationic Protein;
Eosinophils;
Genotype;
Humans;
Immunoglobulin E;
Methacholine Chloride;
Phenotype;
Respiratory Function Tests;
Transforming Growth Factor beta1;
Transforming Growth Factors
- From:Pediatric Allergy and Respiratory Disease
2007;17(3):226-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The -509C/T polymorphism of the transforming growth factor (TGF)-beta1 gene has been associated with asthma and atopy. We evaluate whether TGF-beta1 promoter polymorphism (-509C/T) is associated with the asthma phenotype and the development of atopy in Korean children. METHODS: We enrolled 278 patients with atopic asthma, 54 non-atopic asthma and 248 healthy children. They underwent through pulmonary function tests and methacholine challenge tests with their eosinophil counts of blood, total serum IgE levels and serum eosinophil cationic protein levels. TGF-beta1 promoter polymorphism was genotyped using PCR-restriction fragment length polymorphism (RFLP) assays. RESULTS: No significant difference was observed in allele and genotype frequencies of TGF-beta1 -509C/T polymorphism between the patients with atopic asthma or non-atopic asthma and control subjects. Any pulmonary function or atopic variables were not associated with this polymorphism. Furthermore, we showed that -509C/T polymorphism was not associated with bronchial hyperresponsiveness. CONCLUSION: These results suggest that the -509C/T polymorphism of the TGF-beta1 promoter gene may not be associated with bronchial asthma or atopic variables in Korean children.
