Influence of Taiji quan on the cancer related fatigue and immunity in advanced lung cancer patients with chemotherapy
10.3760/cma.j.issn.1008-6706.2019.01.008
- VernacularTitle:太极拳对中晚期肺癌化疗患者癌因性疲乏的疗效及细胞免疫功能的影响
- Author:
Danhong GE
1
;
Chanchan SHENTU
Author Information
1. 浙江省
- Keywords:
Tai ji;
Exercise movement techniques;
Lung neoplasms;
Antineoplastic combined chemo-therapy protocols;
Fatigue;
Paclitaxel;
Cisplatin;
T-lymphocyte subsets;
Immunity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(1):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of Taiji quan for cancer related fatigue in advanced lung cancer patients with chemotherapy of paclitaxel combined with cisplatin,and its influence on cellular immune function. Methods From June 2016 to December 2017,78 patients with advanced lung cancer in Zhuji Hospital of Traditional Chinese Medicine were selected and randomly divided into observation group and control group by random number table method,with 39 cases in each group. The control group was treated with TP chemotherapy regimens. On the basis of the control group,the observation group was given Taiji quan. Both two groups were observed for 6 weeks. The scores of cancer related fatigue PFS scale,life quality FACT－G scale and short－term curative effect were compared between the two groups. The cellular immune function T －lymphocyte subsets CD+3, CD+3/CD+4, CD+3/CD+8were detected in the two groups. Results The scores of cancer related fatigue(emotion,feeling,behavior,cognition) of the observation group were obviously lower than those of the control group( t=7. 797,12. 385,9. 386,10. 270,all P=0. 000). After treatment,the scores of life quality FACT－G scale(physiological condition,emotional state,society/family state,function state) of the observation group were remarkably higher than those of the control group(t =6. 764, 6. 218,7. 945,8. 026,all P=0. 000). The short－term effective rate of the observation group was 51. 28% (20/39), which was higher than 25. 64% (10/39) of the control group(χ2=4. 388,P=0. 036). After treatment,the levels of CD+3,CD+3/CD+4of the observation group were obviously higher than those of the control group,while the level of CD+3/CD+8was lower than that of the control group,the differences were statistically significant(t=9. 183,9. 327, 4. 848,all P=0. 000). Conclusion Taiji quan can improve cancer related fatigue and life quality,increase short－term curative effect,and can enhance cellular immune function after chemotherapy of paclitaxel combined with cisplatin.
