Research progress of dedifferentiation and mechanism of beta cell in type 2 diabetes mellitus

VernacularTitle:2型糖尿病中β细胞去分化及其机制的研究进展
Author: Wenya WANG ¹ ; Hong QIAO
Author Information

1. 哈尔滨医科大学附属第二医院内分泌与代谢病科
Keywords: Diabetes mellitus,type 2; Pancreatic beta cells; Cell dedifferentiation; Mechanism; Research progress; Review
From: Chinese Journal of Primary Medicine and Pharmacy 2018;25(24):3262-3264
CountryChina
Language:Chinese
Abstract: Islet βcell dysfunction is one of the important links in the development of type 2 diabetes (T2DM).The latest research shows that the main cause of the continuous β-cell dysfunction under metabolic stress is mainly the dedifferentiation of β-cells,and become endocrine progenitor -like cells with multiple differentiation potentials.Studies have found that the process of dedifferentiation of pancreatic islet βcells is reversible.This finding has provided possibilities and new ideas for preventing and reversing the progressive decline of βcell function and delaying the occurrence of T2DM.