Clinical effect of high frequency oscillatory ventilation combined with dobutamine on persistent pulmonary hypertension in neonates
10.3760/cma.j.issn.1008-6706.2018.24.019
- VernacularTitle:高频振荡通气联合多巴酚丁胺应用于新生儿持续性肺动脉高压的临床效果观察
- Author:
Tingtian CHEN
1
Author Information
1. 东阳市人民医院儿科
- Keywords:
Hypertension,pulmonary;
High-frequency ventilation;
Respiration,artificial;
C-reactive protein;
Dobutamine;
Infant,newborn
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(24):3207-3210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of high frequency oscillatory ventilation combined with dobutamine in the treatment of neonates with persistent pulmonary hypertension .Methods From April 2015 to April 2017,62 neonates with persistent pulmonary hypertension in the People＇s Hospital of Dongyang were selected. The patients were divided into control group and experimental group according to the single number,with 31 cases in each group.The experimental group was given high -frequency oscillatory ventilation combined with dobutamine treatment.The control group was treated with constant frequency mechanical ventilation combined with dobutamine . The therapeutic effect,blood gas,analytical indicators,biochemical indicators,pulmonary arterial pressure,systemic systolic blood pressure,oxygen inhalation time,ventilator treatment time,and incidence rate of complication were compared between the two group.Results Compared with the control group ( 76.41%),the effective rate (96.77%) was increased in the experimental group (χ2＝5.16,P＝0.02).The SpO2of the experimental group was (93.03 ±14.06)%,which was higher than (82.15 ±13.87)%of the control group (t＝3.06;P＝0.00).The OI in the experimental group was (17.35 ±1.46),which was lower than (57.36 ±15.36) in the control group ( t ＝14.43;P＝0.00).The CRP,BNP,DD,PAP levels in the experimental group were (2.62 ±0.63) mg/L,(6.19 ± 1.06)ng/L,(7.62 ±1.97)mg/L,(27.65 ±5.06)mmHg,respectively,which were lower than those in the control group [(3.69 ±0.72)mg/L,(8.34 ±1.63)ng/L,(15.72 ±2.81)mg/L,(33.52 ±4.62) mmHg](t＝6.22,6.15,13.14,4.76;P＝0.00,0.00,0.00,0.00).SBP in the experimental group was (71.62 ±6.35) mmHg,which was higher than (65.22 ±6.58)mmHg in the control group (t＝5.29,P＝0.00).The oxygen infusion time,ventilator treatment time of the experimental group were (9.96 ±5.63) d,(18.42 ±5.52) d,respectively,which were longer than those in the control group [(7.21 ±3.45)d,(13.65 ±4.12)d](t＝2.23,3.85,P＝0.02,0.00).The incidence rate of complications in the experimental group was 22.58%,which was lower than 6.45% in the control group (χ2＝6.71,P＝0.00).Conclusion High frequency oscillatory ventilation combined with dobutamine in the treatment of neonatal persistent pulmonary hypertension has better effect and is worthy of clinical promotion .
