Effect of sleep status on thyroid hormone and blood glucose level in hyperthyroidism complicated with diabetes
10.3760/cma.j.issn.1008-6706.2018.24.005
- VernacularTitle:睡眠状况对甲状腺功能亢进症合并糖尿病患者甲状腺激素及血糖水平的影响
- Author:
Jing YANG
1
Author Information
1. 诸暨市人民医院内分泌科
- Keywords:
Hyperthyroidism;
Diabetes mellitus;
Sleep;
Blood glucose;
Thyroxine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(24):3145-3150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different sleep status on thyroid secretion and glucose metab-olism in hyperthyroidism patients complicated with diabetes mellitus.Methods From March 2014 to August 2017,288 hyperthyroidism patients complicated with diabetes in the People ＇s Hospital of Zhuji were selected as study objects.The fasting plasma glucose ( FPG),glycosylated hemoglobin ( HbA1c),serum free three iodine thyroid (FT3),free four iodine thyroid (FT4) and thyroid stimulating hormone (TSH) levels were measured.The patients were grouped according to sleep time (＜6h in 58 cases,≥6 -7h in 102 cases,＞7 -8h in 72 cases,＞8h in 56 cases),sleep quality [ pittsburgh sleep quality index ( PSQI) score ＜7 points in 90 cases,≥7 -12 points in 98 cases,＞12-17 points in 54 cases,＞17 points in 46 cases ] and nap time ( no nap in 63 cases,＜1h in 89 cases,≥1-2h in 100 cases,＞2h in 36 cases),and the levels of FPG,HbA1c,FT3,FT4and TSH among groups were compared.Results There were statistically significant differences in FPG,HbA1c,FT3,FT4and TSH levels among the groups with different sleep quality PSQI scores ( F ＝12.725,15.682,7.026,9.258 and 6.147;P ＝0.000,0.000,0.000,0.000 and 0.000).Comparison of FPG,HbA1c,FT3,FT4and TSH levels in the different sleep time groups,although there were statistically significant differences in the levels of ＜6h,≥6 -7h and ＞7 -8h groups (all P＜0.05),but the levels of each index between the 8h group and the group above ≥6-7h and ＞7-8h group had no statistically significant differences (all P＞0.05).There were statistically significant differences in the levels of FPG,HbA1c,FT3,FT4and TSH among the patients with different nap time (F＝10.925,14.008,9.607,11.120 and 7.251;P ＝0.000,0.000,0.000,0.000 and 0.000).The sleep quality PSQI score was negatively correlated with the levels of FPG,HbA1c,FT3and FT4in patients with hyperthyroidism and diabetes mellitus (r＝-0.856,-0.879,-0.816 and -0.849;P＝0.001,0.000,0.011 and 0.004),and was positively correlated with TSH (r＝0.757,P＝0.021).The nap time was positively correlated with the levels of FPG,HbA1c,FT3and FT4in patients with hyperthyroidism and diabetes mellitus (r＝0.867,0.855,0.793,0.844,P＝0.000,0.000,0.014,0.003),and was negatively correlated with TSH ( r＝-0.802,P＝0.012);but the nocturnal sleep time was not correlated with the levels of FPG,HbA1c,FT3,FT4and TSH in patients with hyperthyroidism and diabetes mellitus (P＞0.05).Conclusion To improve the quality of sleep,sleep at night security appropriate time and increase the sleep midday can effectively reduce the level of blood glucose in diabetic patients with hyperthyroidism and thyroid hormone secretion,improve glucose metabolism and thyroid function.
