The study of the probability and clinical significance of carotid and vertebral atherosclerotic plaque in diabetes
10.3760/cma.j.issn.1008-6706.2018.21.021
- VernacularTitle:糖尿病颈动脉、椎动脉硬化斑块发生率及相关因素分析
- Author:
Xinyi ZHANG
1
Author Information
1. 太原市中铁三局集团中心医院功能检查科
- Keywords:
Diabetes mellitus;
Carotid arteries;
Vertebral artery;
Arteriosclerosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(21):2804-2807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the probability and clinical significance of carotid and vertebral atherosclerotic plaque in patients with diabetes mellitus (DM).Methods From September 2012 to September 2017,465 patients with DM in Taiyuan Central Group Hospital were examined by color Doppler ultrasound.The incidence of carotid plaque,vertebral artery plaque was analyzed,logistic regression analysis was used to analyze the risk factors of atherosclerosis formation and adverse outcomes in DM patients.Results There were 351 cases of arterial plaques,the detection rate was 75.48％,including 69.23％ of carotid arteries,60.97％ of vertebral arteries,61-70 years old accounted for 93.65％,patients with fasting blood glucose ＞ 15.0 mmol/L accounted for 79.17％,DM patients with the course of more than 10 years accounted for 97.80％ of detectable arterial plaque.The age,fasting blood glucose level,duration had statistically significant differences between the plaque group and non plaque group (F =10.564,9.165,10.285,all P ＜ 0.05).Adverse outcomes were observed in 29 DM patients with arterial plaque.The fasting blood glucose level[(15.26 ± 5.93) mmol/L],plaque score [(2.59 ± 0.68) points] in patients with adverse outcomes had statistically significant differences compared with DM patients without adverse outcomes (t =5.646,3.964,all P ＜ 0.05).The results of logistic regression analysis showed that age over 61 years,fasting blood glucose more than 10.1 mmol/L,duration of DM more than 5 years were risk factors of plaque formation in DM patients,the OR values were 1.592 (95％ CI:1.160 ～ 4.237),2.263 (95％ CI:0.952 ～ 8.859),1.095 (95％ CI:2.963 ～ 10.763).The fasting blood glucose level ≥ 15.0mmol/L,plaque score ＞ 2points were risk factors of poor prognosis of DM patients,the OR values were 3.592 (95％ CI:0.956 ～ 6.261),2.913 (95％ CI:1.238 ～ 9.238).Conclusion Patients with DM has a higher risk of carotid artery and vertebral artery plaque,the higher the blood sugar level,the higher the plaque score,the worse the prognosis.
