Advance in biomarkers of neuromyelitis optica
10.3760/cma.j.issn.2095.0160.2018.12.016
- VernacularTitle:视神经脊髓炎生物标志物的研究进展
- Author:
Jun CHEN
1
Author Information
1. 广西医科大学第一附属医院眼科
- Keywords:
Neuromyelitis optica;
Aquaporin.4;
Myelin.oligodendrocyte glycoprotein;
Aquaporin-1;
Glial fibrillary acidic protein
- From:
Chinese Journal of Experimental Ophthalmology
2018;36(12):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica ( NMO ) is an autoimmune, demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis. Aquaporin.4 ( AQP4 ) .IgG is currently regarded as a specific biomarker of NMO. Nevertheless,AQP4.IgG seronegativity in 10％-25％ of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis. In this article,we reviewed current knowledge about biomarkers of NMO from AQP4, myelin.oligodendrocyte glycoprotein, AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.
