Therapeutic effect of pioglitazone combined different drugs on diabetic cardiopathy and its influence on cardiac function
10.3969/j.issn.1008-0074.2018.06.23
- VernacularTitle:吡格列酮联合不同药物治疗糖尿病性心脏病的疗效及对心功能的影响
- Author:
Ling LIU
1
;
Ji-Qing GENG
Author Information
1. 湖北省十堰市妇幼保健院药剂科
- Keywords:
Diabetes mellitus;
Heart disease;
Pioglitazone
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(6):707-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study therapeutic effect of pioglitazone hydrochloride combined different drugs on diabetic cardiopathy (DC) and its influence on cardiac function.Methods:A total of 118 DC patients were selected from our hospital.They were randomly and equally divided into group A (received pioglitazone hydrochloride + nifedipine sustained release tablet ) and group B (received pioglitazone hydrochloride + α-lipoic acid + mecobalamin ),both groups were treated for two months.Related indexes of blood glucose,vascular endothelial function,islet β cell function,heart ejection function before and after treatment,and incidence of adverse reactions were observed and compared between two groups.Results:Compared with before treatment,there were significant reductions in levels of fasting blood glucose (FBG),2h postprandial blood glucose (2hPG),glycosylated hemoglobin A1c (HbA1c),ho-meostasis model-insulin resistance index (HOMA-IR),high sensitive C reactive protein (hsCRP),vascular endothe-lial cell protein C receptor (EPCR),plamsa thrombin regulation protein (TM) and von Willebrand factor (vWF),and significant rise in insulin sensitivity index (ISI),left ventricular ejection fraction (LVEF),left ventricular frac-tional shortening (LVFS) and left ventricular early diastolic peak flow velocity/late diastolic peak flow velocity (E/A) in two groups after treatment,P＝0.001 all.There were no significant difference in above indexes after treat-ment between two groups,P＞0.05 all.No obvious adverse reactions were found in two groups during treatment.Conclusion:Both pioglitazone hydrochloride + nifedipine sustained release tablet and pioglitazone hydrochloride +α-lipoic acid + mecobalamin can significantly reduce blood glucose level,improve insulin resistance,vascular endo-thelial function and cardiac function with low incidence rate of adverse reactions in DC patients,which is worth clin-ical application.
