Correlation among levels of high sensitive C reactive protein,natriuretic peptide,endothelin-1 and nonvalvular atrial fibrillation
10.3969/j.issn.1008-0074.2018.06.09
- VernacularTitle:高敏C反应蛋白、脑钠肽及内皮素-1与非瓣膜性心房颤动的相关性
- Author:
Peng ZHANG
1
;
Rui-Ni ZHANG
;
Fei LI
;
Feng GAO
;
Dong-Yan WANG
Author Information
1. 陕西省延安大学附属医院 心内科
- Keywords:
Atrial fibrillation;
C-reactive protein;
Natriuretic peptide,brain
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(6):650-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore correlation among levels of high sensitive C reactive protein (hsCRP),brain natri-uretic peptide (BNP),endothelin 1 (ET-1) and nonvalvular atrial fibrillation (NVAF).Methods:A total of 124 NVAF patients hospitalized in our department of cardiology were selected.According their heart rhythm character-istics,they were divided into paroxysmal NVAF group (n＝56) and chronic NVAF group (n＝68).Another 48 pa-tients with sinus rhythm,corresponding gender,age,disease condition to NVAF group were simultaneously enrolled as sinus rhythm group.Levels of hsCRP,BNP and ET-1 were measured and compared among all groups.Results:Compared with sinus rhythm group,there were significant rise in levels of hsCRP [ (1.52 ± 0.86) mg/L vs.(2.32 ± 1.38) mg/L vs.(3.35 ± 3.02) mg/L],BNP [ (225.31 ± 70.23) pg/ml vs.(352.42 ± 167.02) pg/ml vs.(403.12 ± 132.05) pg/ml] and ET-1 [ (1.42 ± 0.65) ng/ml vs.(1.96 ± 0.76) ng/ml vs.(2.34 ± 1.15) ng/ml] in paroxys-mal NVAF group and chronic NVAF group,and those of chronic NVAF group were significantly higher than those of paroxysmal NVAF group,P＜0.05 or ＜0.01.Pearson correlation analysis indicated that serum BNP level was significant positively correlated with ET-1 level in NVAF patients (r＝0.325,P＝0.001).Logistic regression analy-sis indicated that levels of BNP,hsCRP and left atrial diameter were independent risk factors for NVAF (OR＝1.42,1.21,1.33,P＜0.05 or ＜0.01).Conclusion:Levels of high sensitive C reactive protein,brain natriuretic peptide and endothelin-1 are closely correlated to nonvalvular atrial fibrillation.
