Role and mechanism of Notch signaling pathway in melanoma growth and metastasis

VernacularTitle:Notch信号通路在黑色素瘤生长、转移中的作用及机制
Author: Dechun XIA ¹ ; Xiaojing KANG
Author Information

1. 832000 石河子大学医学院临床医学系;新疆维吾尔自治区人民医院皮肤性病科
Keywords: Melanoma; Growth; Neoplasm metastasis; Notch signaling pathway
From: Journal of International Oncology 2018;45(10):635-638
CountryChina
Language:Chinese
Abstract: Malignant melanoma is one of the malignant tumors in the skin,which has high invasiveness and stronger ability of metastasis.Its pathogenesis is related to the abnormal conduction of many signal pathways,while the specific mechanism is not completely clear.The abnormal activation of Notch signaling pathway is closely related to the pathogenesis of melanoma.Notch signaling pathway can promote the growth and metastasis of melanoma through maintaining the survival of tumor cells,promoting tumor angiogenesis and enhancing the adhesion and invasiveness of tumor cells.Further understanding of the mechanism of Notch signaling pathway may provide a new target for the treatment of melanoma.