SCD40 ligand expression and inflammatory response in acute aortic dissection patients
10.7507/1007-4848.201807039
- VernacularTitle:Stanford A 型主动脉夹层患者中可溶性 CD40配体表达及炎性反应
- Author:
HAN Lu
1
,
2
;
WANG Xiaolong
2
,
3
;
DAI Lu
2
,
3
;
LAN Feng
3
,
4
,
5
;
ZHANG Hongjia
3
,
4
,
5
Author Information
1. Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, P.R.China;
2. Beijing Lab for Cardiovascular Precision Medicine, Beijing, 100069, P.R.China
3. Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, P.R.China;
4. Beijing Lab for Cardiovascular Precision Medicine, Beijing, 100069, P.R.China;
5. Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, P.R.China
- Publication Type:Journal Article
- Keywords:
Aortic dissection;
cluster of differentiation 40L;
vascular endothelial cells;
inflammatory factors
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(4):301-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of cluster of differentiation 40L (CD40L) between inflammatory response mediated by vascular endothelial injury and Stanford A type aortic dissection (STAAD). Methods In this study from August 2016 to February 2017, a total of 215 blood samples from 95 STAAD patients (67 males and 28 females aged 48.33±12.19 years) and 120 healthy volunteers (94 males and 26 females aged 48.64±10.13 years) were collected. The patients with aortic dissection were taken blood 1 hour before the operation and the healthy volunteers were taken blood from the elbow vein. All STAAD patients were diagnozed by computed tomography angiography (CTA) and patients with Marfan syndrome were excluded. Blood samples were tested by enzyme-linked immunosorbent assay (ELISA) for CD40L, vascular cell adhesion molecule (VCAM-1), E-selectin, interleukin-1 (IL-1) beta, IL-6, tumor necrosis factor-alpha (TNF-α) and so on. Results Compared with the healthy population, the level of SCD40L(26.87±5.50 ng/ml vs. 13.39±4.03 ng/ml, P<0.001) in the STAAD patients was significantly higher. E-Selectin (116.62±25.24 ng/ml vs. 77.05±14.30 ng/ml, P<0.001), VCAM-1 (P<0.001), TNF-α (55.35±9.12 ng/ml vs. 37.33±5.61 pg/ml, P<0.001)，IL-1β (62.12±13.37 ng/ml vs. 48.68±9.86 pg/ml, P<0.001)，IL-6 (499.54±90.45 ng/ml vs. 422.44±34.00 pg/ml, P<0.001) significantly increased. Conclusion The increased expression of SCD40L in STAAD patients and the inflammatory reaction induced by endothelial injury in aortic dissection patients are obvious.
