Neural adaptation of beta adrenergic receptor subtypes after chronic imipramine treatment: A quantitative autoradiographic study.
- Author:
Hae Young PARK
1
;
Young Sook HONG
;
Chan Woong PARK
Author Information
1. Department of Biochemistry, College of Medicine, Ewha Womans University , Seoul Natl. Inst., 110-799 Seoul South Korea.
- Publication Type:Original Article
- Keywords:
Beta adrenergic receptor;
Rat brain;
Autoradigraphy;
Imipramine
- MeSH:
Amygdala;
Animals;
Autoradiography;
Brain;
Cerebral Cortex;
Down-Regulation;
Hippocampus;
Imipramine*;
Rats;
Receptors, Adrenergic*;
Receptors, Adrenergic, beta;
Thalamus
- From:The Korean Journal of Physiology and Pharmacology
1997;1(2):161-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of 3H-dihydroalprenolol (3H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of 3H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala. Significant reductions of the binding of 3H-DHA to beta-2 AR were not found in any area of the brain. These data suggests that a selective down-regulation of beta-1 AR may be involved in the adaptive changes occurring after prolonged imipramine treatment.
