Aggressive Systemic Mastocytosis Following Ovarian Germ Cell Tumor.
10.5045/kjh.2005.40.2.129
- Author:
Eun Ju HUH
1
;
So Young PARK
;
Sang Rhim CHOI
;
Seung Yeon CHUNG
;
Jin Han KANG
;
Kyoung Mee KIM
;
Je Hoon LEE
;
Dae Chul JEONG
Author Information
1. Department of Pediatrics, The Catholic University of Korea College of Medicine, Incheon, Korea. dcjeong@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Germ cell tumor;
Aggressive systemic mastocytosis;
c-kit point mutation
- MeSH:
Bleomycin;
Bone Marrow;
Bone Marrow Examination;
Child, Preschool;
Cisplatin;
Drug Therapy;
Etoposide;
Female;
Germ Cells*;
Humans;
Mast Cells;
Mastocytosis, Systemic*;
Neoplasms, Germ Cell and Embryonal*;
Point Mutation;
Polymerase Chain Reaction;
Skin;
Thrombocytopenia;
Tolonium Chloride
- From:Korean Journal of Hematology
2005;40(2):129-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 4 years-old girl was diagnosed with aggressive systemic mastocytosis at 2 months after the end of chemotherapy including cisplatin, bleomycin and etoposide for an ovarian germ cell tumor (GCT). She was shown pigmented skin lesion, hepatosplenomegaly, thrombocytopenia and increased mast cells with positive toluidine blue staining on the bone marrow examination. Immunohistochemical staining for c-kit was highly expressed in the bone marrow and skin, but not in the GCT specimen. However, c-kit point mutation was detected in the bone marrow, peripheral blood and GCT tissue when performing PCR via oligonucleotide sequencing. We report here on one case of aggressive systemic mastocytosis following ovarian germ cell tumor with c-kit point mutation.
