Successful Treatment of Invasive Gastric Mucormycosis in a Kidney Transplant Recipient.
10.4285/jkstn.2018.32.4.104
- Author:
Hyung Nam KIM
1
;
Sun Ae HAN
;
Ha Yeol PARK
;
Hyun Woo KIM
;
Ran HONG
;
Nam Gyu CHOI
;
Min Ho SHIN
;
Na Ra YOON
;
Hyun Lee KIM
;
Jong Hoon CHUNG
;
Byung Chul SHIN
Author Information
1. Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea. bcshin@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Mucormycosis;
Kidney transplantation;
Stomach
- MeSH:
Abdominal Pain;
Child;
Diabetic Nephropathies;
Endoscopy;
Gastrectomy;
Humans;
Hyphae;
Infant;
Kidney Failure, Chronic;
Kidney Transplantation;
Kidney*;
Middle Aged;
Mucor;
Mucormycosis*;
Mucous Membrane;
Stomach;
Tissue Donors;
Transplant Recipients*;
Transplants
- From:The Journal of the Korean Society for Transplantation
2018;32(4):104-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mucormycosis is an extremely rare but potentially life-threatening fungal infection. Gastrointestinal (GI) mucormycosis is very rare and occurs primarily in highly malnourished patients, especially in infants and children. A 55-year-old man with end-stage renal disease due to diabetic nephropathy, who had undergone deceased donor kidney transplantation 2 years prior, complained of abdominal pain and distension with a 3-day duration. Computed tomography revealed diffuse gastric wall thickening, and a huge amount of grey colored necrotic debris surrounded by erythematous erosive mucosa was observed at the antrum to upper body by GI endoscopy. The microscopic examination obtained from a GI endoscopic specimen demonstrated peptic detritus with numerous non-septate mucor hyphae in the mucosa and submucosa. Mucormycosis was diagnosed based on the clinical findings and morphological features. A total gastrectomy was performed and an antifungal agent was administered. A microscopic examination of the surgical specimen demonstrated invasive mucormycosis with numerous fungal hyphae with invasion into the mucosa to subserosa. The patient and graft were treated successfully by total gastrectomy and antifungal therapy.
