Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection.
- Author:
Jung Ho PARK
1
;
Hyoung Chul PARK
;
Sung Chan PARK
;
Jae Hwan OH
;
Duck Woo KIM
;
Sung Bum KANG
;
Seung Chul HEO
;
Min Jung KIM
;
Ji Won PARK
;
Seung Yong JEONG
;
Kyu Joo PARK
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Colonic neoplasms; Ascending colon; Descending colon; Prognosis; Recurrence
- MeSH: Adenocarcinoma; Colon*; Colon, Ascending; Colon, Descending; Colonic Neoplasms*; Disease-Free Survival; Female*; Follow-Up Studies; Humans; Lymph Nodes; Male; Prognosis; Recurrence; Retrospective Studies
- From:Annals of Coloproctology 2018;34(6):286-291
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer. METHODS: From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS. RESULTS: The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1–134 months). A multivariate Cox regression revealed that female sex (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.19–1.90; P < 0.01), right-sided tumor location (HR, 1.65; 95% CI, 1.29–2.11; P < 0.01), lymphatic invasion (HR, 1.52; 95% CI, 1.08–2.15; P < 0.01) and a high (≥0.4) metastatic lymph node ratio (HR, 3.72; 95% CI, 2.63–5.24; P < 0.01) were independent predictors of worse 5-year DFS. Female patients with RCC were 1.79 fold more likely to experience recurrence than male patients with LCC. CONCLUSION: Female sex and right-sided tumor location are associated with higher tumor recurrence rates in patients with stage-IIIC colon cancers. Aggressive treatment and close surveillance should be planned for patients in these groups.
