Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults.
- Author:
Tae Jun KIM
1
;
Jeung Hui PYO
;
Hyuk LEE
;
Sun Young BAEK
;
Soo Hyun AHN
;
Yang Won MIN
;
Byung Hoon MIN
;
Jun Haeng LEE
;
Hee Jung SON
;
Poong Lyul RHEE
;
Jae J KIM
Author Information
- Publication Type:Original Article
- Keywords: Helicobacter pylori; Inflammation; C-reactive protein
- MeSH: Adult*; Body Mass Index; C-Reactive Protein; Cholesterol; Diabetes Mellitus; Helicobacter pylori*; Helicobacter*; Humans; Hypertension; Immunoglobulin G; Inflammation*; Linear Models; Lipoproteins; Logistic Models; Smoke; Smoking
- From:The Korean Journal of Gastroenterology 2018;72(1):21-27
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large sample of asymptomatic adults. METHODS: Cross-sectional data were obtained from 17,028 adults who completed routine health check-ups. H. pylori infection status was determined using a serum immunoglobulin G test, and systemic inflammation was assessed using the C-reactive protein (CRP) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). RESULTS: Multiple linear regression model-adjusted for potential confounders-revealed that H. pylori infection was not associated with CRP levels (coefficient: −0.012, 95% confidence interval [CI]: −0.037, 0.012, p=0.319), NLR (coefficient: 0.055, 95% CI: −0.027, 0.138, p=0.192), or PLR (coefficient: 1.798, 95% CI: −1.979, 5.574, p=0.351). In a multivariable logistic regression model, H. pylori infection was not associated with the risk of CRP levels being elevated to ≥0.1 mg/dL (odds ratio: 0.96, 95% CI: 0.81, 1.08) or ≥0.3 mg/dL (odds ratio: 1.02, 95% CI: 0.84, 1.19). In the multivariable model, CRP levels elevated to ≥0.1 mg/dL were significantly associated with body mass index, current smoking status, hypertension, and diabetes mellitus. Regular exercise and high-density lipoprotein cholesterol were factors that minimized the elevation of CRP levels. CONCLUSIONS: Chronic infection with H. pylori was not associated with various inflammatory markers. Further investigation is needed to clarify the interaction between H. pylori infection, systemic inflammation, and extra-gastric disease.
