Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases.
- Author:
Young Jae KIM
1
;
Woo Jin LEE
;
Chong Hyun WON
;
Jee Ho CHOI
;
Mi Woo LEE
Author Information
- Publication Type:Case Report
- Keywords: Duodenum; Gastrointestinal stromal tumors; Neoplasm metastasis; Skin
- MeSH: Aged; Brain; Diagnosis; Duodenum; Gastrointestinal Stromal Tumors*; Humans; Imatinib Mesylate; Magnetic Resonance Imaging; Neoplasm Metastasis*; Orbit; Scalp; Skin; Thorax
- From:Annals of Dermatology 2018;30(3):345-347
- CountryRepublic of Korea
- Language:English
- Abstract: We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp. Under the diagnosis with imatinib-resistant duodenal gastrointestinal stromal tumors, a second-line therapy with sunitinib was tried. After six weeks, his skin lesion was completely improved and other metastatic cancers showed a response of stable disease. This is the first reported case of a cutaneous metastasis from duodenal GIST. This report emphasizes the importance of a full-skin examination in patients with a medical history of gastrointestinal stromal tumor which leads to find multiple metastases.
