Increased Risk of Atrial Fibrillation in the Early Period after Herpes Zoster Infection: a Nationwide Population-based Case-control Study.
10.3346/jkms.2018.33.e160
- Author:
Myung Jin CHA
1
;
Hyun Min SEO
;
Eue Keun CHOI
;
Ji Hyun LEE
;
Kyungdo HAN
;
So Ryoung LEE
;
Woo Hyun LIM
;
Young Min PARK
;
Seil OH
Author Information
1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. choiek17@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Atrial Fibrillation;
Herpes Zoster;
Inflammation;
Autonomic Dysfunction
- MeSH:
Atrial Fibrillation*;
Case-Control Studies*;
Diagnosis;
Follow-Up Studies;
Herpes Zoster*;
Hospitalization;
Humans;
Inflammation;
National Health Programs
- From:Journal of Korean Medical Science
2018;33(22):e160-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Herpes zoster (HZ) is a chronic inflammatory disease that could result in autonomic dysfunction, often leading to atrial fibrillation (AF). METHODS: From the Korean National Health Insurance Service database of 738,559 subjects, patients newly diagnosed with HZ (n = 30,685) between 2004 and 2011, with no history of HZ or AF were identified. For the non-HZ control group, 122,740 age- and sex-matched subjects were selected. AF development in the first two-years following HZ diagnosis, and during the overall follow-up period were compared among severe (requiring hospitalization, n = 2,213), mild (n = 28,472), and non-HZ (n = 122,740) groups. RESULTS: There were 2,204 (1.4%) patients diagnosed with AF during follow-up, and 825 (0.5%) were diagnosed within the first two years after HZ. The severe HZ group showed higher rates of AF development (6.4 per 1,000 patient-years [PTPY]) compared to mild-HZ group (2.9 PTPY) and non-HZ group (2.7 PTPY). The risk of developing AF was higher in the first two-years after HZ diagnosis in the severe HZ group (10.6 PTPY vs. 2.7 PTPY in mild-HZ group and 2.6 PTPY in non-HZ group). CONCLUSION: Severe HZ that requires hospitalization shows an increased risk of incident AF, and the risk is higher in the first two-years following HZ diagnosis.
