A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms.
- Author:
Karen M JIMÉNEZ
1
;
Angela J PEREIRA-MORALES
;
Diego A FORERO
Author Information
- Publication Type:Original Article
- Keywords: Dopamine receptors; Depression; Mental health; miRNAs; Neuropsychiatry
- MeSH: Binding Sites; Depression*; Humans; Linear Models; Mental Health; MicroRNAs; Models, Genetic; Neuropsychiatry; Receptors, Dopamine
- From:Psychiatry Investigation 2018;15(4):402-406
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and genotyped for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used. RESULTS: A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094). CONCLUSION: These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology.
