Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma.
10.4174/astr.2018.94.3.129
- Author:
Jong Man KIM
1
;
Nam Joon YI
;
Choon Hyuck David KWON
;
Kwang Woong LEE
;
Kyung Suk SUH
;
Jae Won JOH
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. chdkwon@skku.edu
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Hepatectomy;
Recurrence;
Tumor biomarker;
Survival
- MeSH:
Carcinoma, Hepatocellular*;
Causality;
Early Intervention (Education);
Hepatectomy;
Humans;
Incidence;
Liver*;
Multivariate Analysis;
Portal Vein;
Prognosis;
Recurrence*;
Retrospective Studies;
Risk Factors;
Survival Rate;
Thrombosis
- From:Annals of Surgical Treatment and Research
2018;94(3):129-134
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Although few hepatectomy patients develop unexpected early diffuse and multinodular recurrence in the remnant liver, the prognosis in such cases is often dismal. The aim of this study was to evaluate the risk factors of early disseminated multinodular hepatocellular carcinoma (HCC) recurrence within 3 months after liver resection for solitary HCC. METHODS: Eighty-four patients who were diagnosed with recurrent HCC within 3 months after hepatectomy for solitary HCC were retrospectively reviewed. Disseminated HCC recurrence was defined as more than 10 tumors in both lobes and total tumor size >10 cm. RESULTS: Preoperative α-FP level, incidence of poor tumor grade, and presence of portal vein tumor thrombosis were higher in the patients with disseminated HCC recurrence than in those without disseminated HCC recurrence (P < 0.05). Multivariate analysis showed that α-FP >1,000 ng/dL was a predisposing factor of disseminated HCC recurrence within 3 months after liver resection. The overall survival rate for patients without disseminated HCC recurrence was higher than that for patients with disseminated HCC recurrence (P < 0.001). CONCLUSION: Early disseminated multinodular HCC recurrence in hepatectomy patients was associated with preoperative α-FP >1,000 ng/dL. Such patients should be frequently evaluated for the early detection of recurrent HCC for early intervention.
