Endoscopic and clinicopathological features of young, middle-aged, and elderly patients with advanced gastric cancer in Fuzhou area
10.3760/cma.j.issn.1006-9801.2018.04.006
- VernacularTitle:福州地区青年与中老年胃癌患者内窥镜下表现及临床病理特征分析
- Author:
Shishun ZHONG
1
;
Wei LIN
;
Wei LIANG
;
Xiaoling ZHENG
;
Liang CHEN
Author Information
1. 福建医科大学省立临床医学院 福建省立医院消化内镜中心
- Keywords:
Gastric neoplasms;
Pathology;
Endoscopes;
Youth;
Middle aged;
Aged
- From:
Cancer Research and Clinic
2018;30(4):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the endoscopic and clinicopathological features between the young,middle-aged,and elderly patients with advanced gastric cancer in Fuzhou area. Methods The clinical data of 2 357 patients with advanced gastric cancer in digestive endoscopy center of Fujian Provincial Hospital from January 2010 to December 2015 were collected. All cases were divided into two groups, the youth group with age ≤40 years old, and the middle-aged and elderly group with age > 40 years old. The gender, pathological type, cancer position and endoscopic typing of patients were compared between the two groups by using chi-square test. Results In the whole 2 357 patients, the male to female ratio was 2.71:1. The youth group had 120 cases (5.09 %), the male to female ratio was 1:1.07. The middle-aged elderly group had 2 237 cases (94.91 %), the male to female ratio was 2.90:1. The incidence of middle part gastric cancer in youth group was significantly higher than that in middle-aged and elderly group [43.33 % (52/120) vs. 25.75 %(576/2 237),χ2=18.018,P =0.000], however the incidence of upper part gastric cancer in middle-aged and elderly group was significantly higher than that in youth group [27.58 % (617/2 237) vs. 6.67 % (8/120), χ2= 25.568, P = 0.000]. Borrmann Ⅲ type were common in the two groups, but the proportion of Borrmann Ⅰ type in middle-aged and elderly group was significantly higher than that in youth group [20.79 % (465/2 237) vs. 11.67 % (14/120), χ 2= 5.850, P = 0.016], the proportion of Borrmann Ⅳ type in youth group was significantly higher than that in middle-aged and elderly group [23.33 % (28/120) vs. 11.27 %(252/2 237),χ2=15.845,P =0.000].As compared with the middle-aged and elderly patients,youth patients had worse differentiation and growth type (P < 0.01). There were no significant differences in each index between male and female in the youth group (all P > 0.05). In the middle-aged and elderly group, the incidence of upper part gastric cancer in male group was higher than that in female group[29.03 %(483/1 664) vs. 23.39 % (134/573), χ 2= 6.790, P = 0.009], the incidence of middle part gastric cancer in female group was higher than that in male group [31.06 % (178/573) vs. 23.92 % (398/1 664), χ 2= 9.415, P = 0.002]. In the middle-aged and elderly group, the female patients had worse differentiation than the males (P < 0.01). Conclusions There are differences in the endoscopic and clinicopathological features between young, middle-aged, and elderly patients with advanced gastric cancer in Fuzhou area. In young patients, the proportion of patients with middle part gastric cancer is high, while in middle-aged and elderly patients, the proportion of upper part gastric cancer is high.Compared with the middle-aged and elderly patients,the young patients have worse differentiation.
