Advances in diagnostic criteria and biomarkers for neonatal acute kidney injury

VernacularTitle:新生儿急性肾损伤诊断及生物标记物研究进展
Author: Yingying WANG ¹ ; Yun CAO
Author Information

1. 复旦大学附属儿科医院新生儿科
Keywords: Acute kidney injury; Biomarkers; Incidence; Infant,newborn
From: Chinese Journal of Perinatal Medicine 2018;21(9):626-631
CountryChina
Language:Chinese
Abstract: Acute kidney injury (AKI) has a high incidence in neonates. A variety of perinatal factors may contribute to neonatal AKI, resulting in short- and long-term adverse outcomes, including chronic kidney disease. Early diagnosis and timely treatment can significantly improve the outcomes of these babies. Diagnostic criteria for AKI in adults and children are inapplicable to neonates due to the specific pathophysiological characteristics in newborns. In addition, current diagnosis criteria for neonatal AKI are still inconsistent. These all make it more difficult to diagnose neonatal AKI accurately. New biomarkers for kidney injury, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin-18, have been found valuable for early and accurate diagnosis and prognosis of neonatal AKI. However, more studies are required to clarify the influencing factors, diagnostic values and clinical significance of those biomarkers.