Microbiota and neonatal diseases
10.3760/cma.j.issn.1007-9408.2018.07.003
- VernacularTitle:菌群与新生儿疾病
- Author:
Jialin YU
1
Author Information
1. 518000,深圳大学总医院儿科
- Keywords:
Infant,newborn,diseases;
Microbiota;
Biodiversity
- From:
Chinese Journal of Perinatal Medicine
2018;21(7):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Microbiota is closely related to human health and diseases,while it is affected by many factors in neonates.We summarized our primary research on gut microbiota and the associated neonatal diseases.Pathogenic bacteria may cause neonatal ventilator associated pneumonia (VAP) by the form of biofilms.Straptococcus spp.,commonly seen in neonatal oropharynx,facilitate pathogenic process through secretion of autoindueer-2 (AI-2).Significantly increased Proteobacteria and decreased Firmicutes in gut tissues and feaces in neonates with necrotizing enterocolitis (NEC) are associated with deficiency of short chain fatty acids (SCFAs)and impaired differentiation of regulatory T cells (Treg).One-week empirical antibiotic therapy for neonatal early-onset septicemia may remarkably affect the diversity of gut microbiota in early life,which is likely to damage the intestinal mucosal barrier.Obvious deficiency of intestinal Bacteroides in newborns born abdominally will delay the establishment of a healthy and balanced intestinal flora.
