Autonomic disturbances in narcolepsy type 1
10.3760/cma.j.issn.1006-7876.2018.08.014
- VernacularTitle:发作性睡病1型与自主神经功能紊乱
- Author:
Bei HUANG
1
;
Kun CHEN
;
Zhongxin ZHAO
;
Huijuan WU
Author Information
1. 海军军医大学附属长征医院神经内科
- Keywords:
Narcolepsy;
Hypocretin;
Autonomic nervous system
- From:
Chinese Journal of Neurology
2018;51(8):630-634
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of narcolepsy type 1 is characterized by massive loss of hypocretin neurons in the lateral hypothalamus.Due to the extensive interaction between the hypocretin signalling pathway and the autonomic nerve centre of brain stem and spinal cord,narcolepsy type 1 patients often showed autonomic nervous dysfunctions,such as circadian rhythms/sleep abnormalities,energy metabolism and body temperature regulation disorder,pupil adjustment disorder,sexual dysfunction and autonomic fluctuations during cataplexy.We reviewed the autonomic dysfunction of the narcolepsy type 1 patients in general and during cataplexy,in order to strengthen the attention to autonomic nervous dysfunction in narcolepsy type 1.
