Diagnosis and treatment of graft-versus-host-disease after kidney transplantation: A Case Report and Literature Review
10.3760/cma.j.issn.0254-1785.2018.04.003
- VernacularTitle:肾移植后移植物抗宿主病一例的诊治
- Author:
Dunfeng DU
1
;
Ping ZHOU
;
Hui GUO
;
Yuanyuan ZHAO
;
Zhishui CHEN
;
Jipin JIANG
Author Information
1. 华中科技大学同济医学院附属同济医院器官移植研究所器官移植教育部重点实验室卫生部器官移植重点实验室
- Keywords:
Kidney transplantation;
Graft-versus-host-disease;
Short tandem repeats;
Immunofluorescent staining
- From:
Chinese Journal of Organ Transplantation
2018;39(4):203-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis and treatment of graft-versus-host-disease (GVHD) after solid organ transplant (SOT) and the possible mechanism.Methods In this study,we retrospectively reported a rare case of GHVD after kidney transplantation and performed a literature review.This 51 year old male patient presented with over 10-day history of sporadic skin rash on postoperative day 50.Skin biopsy examination revealed GVHD.For further clear diagnosis,patient's peripheral blood was collected immediately for short tandem repeats (STR) enriched for CD3+ cells and we also performed immunofluorescent staining for patient's skin with specific HLA-A11 antibody,one of donor specific HLA sites.Meanwhile,the decreased immunosuppression was used for treatment.Results In our report,chimerism analysis by STR revealed no chimerism in patient's peripheral blood.However,immunofluorescent staining of patient's skin demonstrated abundant donor-derived lymphocytic infiltration existed.GVHD was definitely made in this case.After treatment with decreased immunosuppression and a low dose of methylprednisolone (MP),his clinical symptom was quickly alleviated.Now the patient was discharged and the renal function was normal.Conclusion Combined with literature review and our case report,we thought that chimerism analysis by STR and immunofluorescent staining by donor-specific HLA antibody were very useful for diagnosis of GVHD after SOT.Furthermore,GVHD referred to over-immunosuppression and prognosis of GVHD after kidney transplantation is usually satisfactory.
