Early progression of mild ischemic stroke in the elderly
10.3969/j.issn.1009-0126.2018.04.017
- VernacularTitle:老年轻型缺血性脑卒中早期进展的临床研究
- Author:
Xin LIU
1
;
Xiaogang LI
;
Hongxia WANG
;
Lijuan WANG
;
Ying LIU
Author Information
1. 100190,北京市中关村医院神经内科
- Keywords:
stroke;
C-reactive protein;
brain infarction;
ischemic attack,transient;
homocysteine;
diabetes mellitus
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(4):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors for early neurological deterioration (END) in elderly mild ischemic stroke (MIS) patients.Methods Two hundred MIS patients with their national institute of health stroke scale (NIHSS) score≤3 admitted to the Beijing Zhongguancun Hospital from June 2013 to July 2017 were divided into progressive ischemic stroke group (n=52) and nonprogressive ischemic stroke group (n =148).Their past medical history,clinical symptoms,laboratory testing parameters,and imaging data were compared and analyzed.Results The incidence of diabetes mellitus and ischemic stroke,abnormal circadian rhythm of blood pressure,NIHSS score,serum hs-CRP level,incidence of blood vessel stenosis or occlusion,multiple lesions and watershed cerebral infarction were significantly higher in progressive ischemic stroke group than in non-progressive ischemic stroke group (P ＜ 0.05,P ＜ 0.01).Multivariate logistic regression analysis showed that hs-CRP,abnormal circadian rhythm of blood pressure,blood vessel stenosis or occlusion,multiple lesions,and watershed cerebral infarction were the independent risk factors for END in elderly MIS patients (OR=3.113,95％CI:1.483-6.532,P=0.003;OR=2.724,95％CI:1.291-5.749,P=0.009;OR=3.499,95％CI:1.557-7.860,P=0.002;OR =2.794,95％CI:1.359-5.744,P=0.005;OR=3.843,95％CI:1.752-8.426,P=0.001).Conclusion hs-CRP,abnormal circadian rhythm of blood pressure,blood vessel stenosis or occlusion,multiple lesions and watershed cerebral infarction are the independent risk factors for END in elderly MIS patients.
