Value of urinary neutrophil gelatinase-associated lipocalin in predicting carotid atherosclerosis in elderly type 2 DM patients
10.3969/j.issn.1009-0126.2018.04.016
- VernacularTitle:尿中性粒细胞明胶酶相关脂质运载蛋白预测老年2型糖尿病患者颈动脉硬化的价值
- Author:
Ling ZHANG
1
;
Chen LU
;
Shufen YANG
;
Beili·jiapaer
Author Information
1. 新疆医科大学新疆维吾尔自治区人民医院干部保健科
- Keywords:
diabetes mellitus,type 2;
carotid artery diseases;
glomerular filtration rate;
urine;
forecasting;
neutrophil gelatinase-associated lipocalin
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(4):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Objetive To study the value of urinary neutrophil gelatinase associated lipocalin (NGAL) in predicting carotid atherosclerosis in elderly type 2 DM patients.Methods Two hundred and twenty-five elderly type 2 DM patients were divided into urinary NGAL≤42 ng/mg group (n=100) and urinary NGAL＞42 ng/mg group (n=125).Their clinical data were retrospectively analyzed.Risk factors for carotid atherosclerosis were recorded.The value of risk factors in predicting carotid atherosclerosis was assessed according to the area under the ROC curve.Results The incidence of carotid atheroslerotic plaques was significantly lower in urinary NGAL≤42 ng/mggroup than in urinary NGAL＞42 ng/mg group (32.0％ vs 57.8％,P＜0.05).Age,NGAL,urinary microalbumin/creatinine (ACR),LDL-C,TC,hypertension were positively related with carotid atherosclerosis (P＜0.05) and eGFR was negatively related with carotid atherosclerosis (P＜0.05).Urinary NGAL and ACR were two risk factors for carotid atherosclerosis after adjustment for age,hypertension,hyperlipidemia,and eGFR (P＜0.05).The area under the ROC curve for predicting carotid atherosclerosis was 0.87 and 0.78 respectively.Conclusion Urinary NGAL is an independent risk factor for carotid atherosclerosis in type 2 DM patients.The accuracy of urinary NGAL is higher than that of urinary ACR in predicting carotid atherosclerosis.
