Current opinions on the viral etiology of leukemia
10.3969/j.issn.1000-8179.2018.07.072
- VernacularTitle:白血病病毒病因的现代观
- Author:
Kefu WU
1
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
Author Information
1. 中国医学科学院
- Keywords:
leukemia;
viruses;
etiology;
oncogenic viruses;
retroviruses
- From:
Chinese Journal of Clinical Oncology
2018;45(7):325-330
- CountryChina
- Language:Chinese
-
Abstract:
Half a century ago,it was confirmed that leukemia could be induced by retroviruses in some animals.There are numerous en-dogenous retroviruses in the human genome.However,retrovirus-related human adult T-cell leukemia is only endemic in some local areas. Recently,an extensive study on apolipoprotein B mRNA editing enzyme catalytic polypeptide 3(APOBEC3)family members has revealed the resistance mechanism in human to retrovirus-induced leukemia.The Epstein-Barr virus is widely spread in the human population and exists as a latent infection in the human body for a long time.It is closely associated with the occurrence and development of some lymphomas and solid tumors,indicating its tumorigenicity.The relationship between other viral infections and leukemia/lymphoma remains unclear. The interaction may be mediated by complex,multistep,and indirect networks,which need to be further illuminated.
