Advances in targeted therapy of gastric cancer
10.3969/j.issn.1000-8179.2018.04.546
- VernacularTitle:胃癌靶向治疗的研究进展
- Author:
Tingting PAN
1
;
Weizuo CHEN
Author Information
1. 兰州大学第一临床医学院 兰州市730000
- Keywords:
gastric cancer;
targeted therapy;
EGFR;
VEGF;
PD-1/PDL-1;
CTLA-4;
microRNA
- From:
Chinese Journal of Clinical Oncology
2018;45(4):209-213
- CountryChina
- Language:Chinese
-
Abstract:
Progress in the treatment of gastric cancer(GC)is a major concern because GC is a common cancer worldwide.Recently,by studying the molecular mechanisms of GC,researchers learned that GC progression involved a series of changes at the molecular lev-el,including the activation of signaling pathways,abnormal expression and mutation of genes,and response to related targeted drugs used in clinics.However,many targeted drugs produce resistance in a short period of time because of complicated cellular,microenvi-ronmental,and genetic instabilities.Therefore,it is important to find new targets against GC.In this review,we present the current re-search status and progress with respect to GC targets.
