Hyponatremia and Generalized Edema Associated with Ibuprofen Therapy in a Neonate.
- Author:
So Hee KIM
1
;
Eun Young KIM
;
Sang Kee PARK
Author Information
1. Department of Pediatrics, College of Medicine Chosun University, Gwangju, Korea. skpark@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Ibuprofen;
Hyponatremia;
Generalized edema;
Neonate
- MeSH:
Anorexia;
Constipation;
Dizziness;
Ductus Arteriosus, Patent;
Dyspepsia;
Eating;
Edema*;
Exanthema;
Humans;
Hyponatremia*;
Ibuprofen*;
Indomethacin;
Infant;
Infant, Newborn*;
Infant, Premature;
Nausea;
Prostaglandin-Endoperoxide Synthases;
Tinnitus;
Vomiting
- From:Journal of the Korean Society of Neonatology
2006;13(1):176-179
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ibuprofen is a nonsteroidal anti-inflammatory, analgesic, and antipyretic agent which has used for the treatment of rheumatoid and musculoskeletal disorders. Its side effects have generally been minor; these include dyspepsia, anorexia, nausea and vomiting, constipation, rashes, dizziness, and tinnitus. Ibuprofen is a prostaglandin synthetase inhibitor that is not recommended for neonates. It is pharmacologically similar to indomethacin, which is used to treat symptomatic patent ductus arteriosus in premature infants. We report here a case of a term infant who developed severe hyponatremia and generalized edema associated with the ingestion of an overdose of ibuprofen. The baby made a complete recovery.
