Simultaneous Determination of Borneol and Camphor in Xingkening Capsules by GC
- VernacularTitle:气相色谱法同时测定心可宁胶囊中樟脑和冰片的含量
- Author:
Shi LUO
1
;
Jing QIU
;
Ruilian LI
;
Zhenyu PAN
Author Information
1. 湖南省药品检验研究院 长沙410001
- Keywords:
Xingkening capsules;
Borneol;
Camphor;
GC;
Content determination
- From:
China Pharmacist
2018;21(10):1881-1883
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a GC method for the determination of borneol and camphor in Xingkening capsules. Methods:A capillary column using polyethylene glycol 20000 (PEG-20M) as the stationary phase (30 m×0. 53 mm,1 μm) was employed. The flow rate of carries gas (N2) was 3. 0 ml·min-1. The inlet temperature was 200℃, the temperature of flame ionization detector was 210℃, the column temperature was 140℃, and the split ratio was 1 ∶ 1. Results: The linear range of borneol was 13. 25-1 325. 19 μg·ml-1(r=0. 999 9), and the average recovery was 100. 22% with the RSD of 0. 92% (n=6). The linear range of camphor was 1. 029-16. 464 μg·ml-1(r=0. 997 5),and the average recovery was 98. 89% with the RSD of 2. 78% (n=6). Conclusion: The method is simple, accurate and reliable, which can be used for the quality control of borneol and camphor in Xingkening capsules.
