Preparation and in vitro Dissolution of Febuxostat Nanosuspension Sustained-release Pellets
10.3969/j.issn.1008-049X.2018.03.010
- VernacularTitle:非布司他纳米缓释微丸的制备与体外释放度研究
- Author:
Chen YAO
1
;
Yan ZHANG
Author Information
1. 解放军第161医院药剂科 武汉430022
- Keywords:
Febuxostat;
Nanosuspension;
Sustained-release pellets;
In vitro dissolution;
Drug release mechanism
- From:
China Pharmacist
2018;21(3):415-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare febuxostat nanosuspension and prepare sustained-release pellets,and investigate the in vitro dis-solution.Methods: Febuxostat nanosuspension was prepared by a high pressure homogenization method. Febuxostat nanosuspension pellets were prepared by fluidized bed coating technique. Eudragit RL30D and Eudragit RS30D were used to prepare the sustained-re-lease pellets. The dissolution mechanism of febuxostat nanosuspension sustained-release pellets was evaluated. Results: The average particle size of the prepared febuxostat nanosuspension was (212.5 ± 36.3) nm, PdI was (0.193 ± 0.018), zeta potential was ( -12.4 ± 0.3) mV,and the scanning electron microscopy showed that the particle size distribution of febuxostat nanosuspension was narrow. The in vitro dissolution of febuxostat nanosuspension sustained-release pellets was more stable and conformed to the first-order release model. Conclusion: The in vitro dissolution of febuxostat nanosuspension sustained-release pellets is more stable, and the preparation provides a new choice for febuxostat clinical application.
