Medication Analysis on One Patient with Epilepsy after Mechanical Valve Replacement of Mitral Valve
- VernacularTitle:1例二尖瓣机械瓣膜置换术后合并癫痫患者脑出血的用药分析
- Author:
Lewei SUN
1
;
Wen ZHANG
;
Bei GAO
Author Information
1. 天水市第三人民医院药械科 甘肃天水741000;甘肃省人民医院药剂科
- Keywords:
Warfarin;
Magnesium valproate;
Cerebral hemorrhage;
Epilepsy;
Levetiracetam
- From:
China Pharmacist
2017;20(11):2029-2031
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the mechanism of the high risk factors for hemorrhage by the study on the combination of warfa-rin and magnesium valproate to provide reference for the rational drug selection. Methods:Clinical pharmacists analyzed and adjusted the antiepileptic drug treatment scheme for one patient with cerebral hemorrhage induced by the combination of warfarin and magnesium valproate after mitral valve replacement complicated with epilepsy.The adjusted scheme was as follows:magnesium valproate was sus-pended,0.25 g levetiracetam was used,po,bid,and then the dose was raised to 0.5 g after 14 days for the anti-epileptic treatment. Pharmaceutical care was performed during the whole process of the treatment. Results: After 20-day hospital stay, the international normalized ratio (INR) was controlled within the range of 2.5-3.0,and the patient was discharged in stable conditions with no occur-rence of epilepsy. Conclusion:Levetiracetam has few interactions with warfarin,suggusting the combination is reasonable.
