Study of axonal guidance growth cue netrin-1 on nano-materials in nerve regeneration
10.3867/j.issn.1000-3002.2017.12.008
- VernacularTitle:netrin-1在纳米材料修复神经损伤中的作用机制研究进展
- Author:
Zheng-Tai JIA
1
;
Zhi-Fa ZHANG
;
Yu-Chen ZHAO
;
Mei-Li LIU
Author Information
1. 北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室
- Keywords:
nanomaterials;
netrin-1;
neurons;
toxicity;
neuronal regeneration
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(12):1201-1207
- CountryChina
- Language:Chinese
-
Abstract:
Nerve regeneration is a major problem in our society after nerve injury.With the development of nanotechnology,some nano-materials,such as carbon nanotubes and graphene with electrical conductivity,have been used to promote neuronfunctional recovery.Some of the nano-materials,however,are neurotoxic and cause neuronal apoptosis.Nerve injury often leads to the disruption of axons,and broken axons cannot form synapse with target neurons,which affects the repair and regeneration of nerves.Netrin-1 is an important cue in neurogenesis,which can guide the growth and migration of axons and synapse formation during neuronal regeneration.However,some growth factors are used to decorate the surface of nanomateriaes to decrease the toxicity in medicine,but the molecular mechanism by which netrin-1 mediates the toxicity of nanomaterials is not clear yet.In this study,we investigated the nano-materials and the function of netrin-1 in neuronal regeneration in recent years.We have proved that netrin-1 can not only guide the growth and migration of axon and synapse formation,but also promote functional recovery of the neurons which are injured by the toxicity of nanomaterials.Our review will provide a theoretical basis for neuronal regeneration by nanomaterials.
