Research advances in cardiovascular protective effects of flavonoids
10.3969/j.issn.1001-1978.2018.06.001
- VernacularTitle:黄酮类化合物的心血管保护作用机制研究进展
- Author:
Xu-Guang LI
1
;
Lian-Hua FANG
;
Guan-Hua DU
Author Information
1. 中国医学科学院北京协和医学院药物研究所
- Keywords:
flavonoids;
cardiovascular disease;
mechanism;
antioxidation;
anti-inflammation;
vasodilation
- From:
Chinese Pharmacological Bulletin
2018;34(6):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids are a large class of bioactive compounds widely found in food and plants. Studies have found that they have a good preventive and therapeutic effect on cardiovascular diseases. Flavonoids have a wide range of pharmacological effects, including antioxidation, anti-inflammation, vasodila-tion, inhibiting platelet aggregation and regulating blood lipids and so on. The cardiovascular protective mechanism of fla-vonoids involves the enzymes that inhibit the production of oxy-gen derived free radicals, inhibition of lipid peroxidation and in-flammatory factor, down-regulation of epoxy synthase activity and activation of AMPK and nuclear factor kappa B signaling pathway. In this review we summarize the so far acquired knowl-edge of the most important mechanisms of flavonoid action, so as to provide the theoretical basis for the research and development of the active monomers in flavonoid and compound preparations.
