Diagnostic Significance of Serum Soluble CD146 Level in Early-stage Diabetic Nephropathy

VernacularTitle:血清可溶性CD146水平在早期糖尿病肾病诊断中的作用
Author: Bo LIU ¹ ; Sheng YANG
Author Information

1. 中国医科大学附属盛京医院实验研究中心动物实验室
Keywords: soluble CD 146; early-stage diabetic nephropathy; renal damage
From: Journal of China Medical University 2017;46(11):1005-1008
CountryChina
Language:Chinese
Abstract: Objective To investigate serum soluble CD146 (sCDl46) level in early-stage diabetic nephropathy.Methods Thirty-two SPF-class SD rats were randomly divided into 2 groups as follows:a control group (C group,n =16) and a model group (DN group,n =16).Serum creatinine (Scr),blood urea nitrogen (BUN),sCDl46 level,and renal weight-to-body weight ratio (RW/BW) were estimated at the first day (D 1) and third week (W3) after modelling.Periodic acid-Schiff staining was used for observing the renal cortex and calculating the renal glomerular mesangial membrane area (MMA).Results The serum sCD146 level was significantly higher in the DN group at D1 and W3 (P ＜ 0.05) compared with that in the C group.RW/BW and MMA were significantly higher in the DN group than in the C group (P ＜0.01).Conclusion Serum sCD146 level reacts to increases much sooner and faster in the DN model,which could be used as a sensitive diagnostic index to reflect the severity of early renal damage.