Analysis of the Clinical Significance of Bone Morphogenetic Protein 2 in Glioblastoma Multiforme

VernacularTitle:骨形成蛋白2在脑多形性胶质母细胞瘤中的表达及临床意义
Author: Shaoxiao ZHANG ¹ ; Ying WU
Author Information

1. 辽宁省盘锦市中心医院VIP病房
Keywords: bone morphogenetic protein 2; glioblastoma multiforme; the cancer genome atlas; gene expression omnibus
From: Journal of China Medical University 2017;46(11):976-979
CountryChina
Language:Chinese
Abstract: Objective To investigate the prognostic significance of bone morphogenetic protein 2 (BMP2) expression in glioblastoma multiforme (GBM) and related pathways.Methods RNASeqV2 data and GSE7696 series matrix data were downloaded from The Cancer Genome Atlas (TCGA) and The Gene Expression Omnibus (GEO) database,respectively.The correlation between BMP2 expression and prognosis was evaluated using Kaplan-Meier and multivariate COX analysis.Gene set enrichment analysis (GSEA) was used to predict the functional gene sets and/or pathways modulated by BMP2.Results Decreased expression of BMP2 is an independent predictor of poor prognosis.Furthermore,genes that are upregulated in response to interferon-α proteins were enriched in samples with low BMP2 expression.Conclusion Low expression of BMP2 indicates poor prognosis in GBM patients.Genes that are upregulated in response to interferon-α proteins may also be implicated in prognosis.