Study on Dynamic Upwarp State Correction Coefficient of Cyclosporine Blood Concentration Determined by EMIT
10.6039/j.issn.1001-0408.2018.08.16
- VernacularTitle:EMIT法检测环孢素血药浓度的动态飘逸校正系数研究
- Author:
Qingwu ZHOU
1
Author Information
1. 绵阳市中心医院药学部
- Keywords:
EMIT;
Cyclosporine;
Blood concentretion;
Dynamic upwarp state;
Correction coefficient
- From:
China Pharmacy
2018;29(8):1078-1082
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the dynamic upwarp state correction coefficient of cyclosporine blood concentration determined by EMIT. METHODS:The dynamic upwarp state of cyclosporine concentration was determined by EMIT. The cyclosporine calibration reagents with concentration of 100 ng/mL was used as the sample to be measured,the 58th and 101st test results were selected to simulate the dynamic upwarp state related coefficients,and the 1st,20th,45th,77th,106th,115th test results were corrected by above coefficients. The difference of correction quality concentration with real quality concentration was investigated. RESULTS:The dynamic upwarp state coefficient [k=(1+0.001 235×n0.419 5)n] and dynamic upwarp state correction coefficient {k′=1/[(1+0.001 235×n0.419 5)n} were obtained. After determination results were corrected,relative error of corrected quality concentration with real quality concentration was within ± 4%.CONCLUSIONS:The obtained dynamic upwarp state correction coefficient can be used for dynamic calibration of cyclosporine quality control concentration,which contribute to correct determination of blood concentration of cyclosporine.
