Pathogenetic and therapeutic roles of non-coding RNAs on major depressive disorder
10.3760/cma.j.issn.1674-6554.2018.04.018
- VernacularTitle:非编码RNA在抑郁症发病和治疗过程中的调控作用
- Author:
Yu CHEN
1
;
Zhijian YAO
Author Information
1. 210029 南京,南京医科大学附属脑科医院心境障碍科,江苏省抑郁症诊疗中心
- Keywords:
Non-coding RNA;
Major depressive disorder;
Antidepressant;
Treatment
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(4):377-380
- CountryChina
- Language:Chinese
-
Abstract:
The major depressive disorder (MDD) affecting a large amount of population still has unknown neurobiological mechanisms and dissatisfactory treatment response.Given the urgently need for effective predictive markers for diagnosis and treatment,epigenetic studies of neuropsychiatric disorders including non-coding RNAs (ncRNAs) expand the research.Non-coding RNAs including microRNA,long noncoding RNA and circular RNA,may play important roles on neural differentiation,synaptic plasticity and central neurological reaction of stress during the course of antidepressasnt treatment.The current knowledge was summarized about posttranscriptional regulation of ncRNAs in major depression and discussed the potential biomarker value of ncRNAs for treatment evaluation in the context of individualized treatment.
