Clinical research about the correlation between Fas、FasL protein and breast cancer
10.3969/j.issn.1009-9905.2017.12.007
- VernacularTitle:Fas、FasL蛋白与乳腺癌相关性的临床研究
- Author:
Hao-Yuan SHEN
1
;
Chun-Yan DENG
;
Yi-Fei DAI
;
Yun-Tao HAN
;
Dong-Jie PENG
;
You-Lin YU
;
Yuan-Bing XU
;
Pai PENG
;
Chao-Hua HU
Author Information
1. 武汉科技大学附属孝感医院 甲乳外科 湖北 武汉432000
- Keywords:
Breast cancer;
Fas;
FasL;
Ki-67;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(12):948-951
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of the expression of Fas and FasL in breast cancer tissue and their relationship with the prognosis of breast cancer.Methods:Immunohistochemical technique was used to detect protein expression proportion and the level of Fas and FasL in 60 cases of breast cancer and 10 cases of benign breast tumor tissues.the experimental data were analyzed using semi-quantitative count and SPSS22.Results:The positive rate of Fas,FasL in breast cancer and benign breast tumor tissues were 78.33％ (47/60),80％ (8/10) and 95％ (57/60),70％(7/10),the positive rate of Fas protein in breast cancer tissues was higher than that of benign breast tumors,the positive rate of FasL protein in breast cancer was lower than that in benign breast tumor tissue.Fas、FasL protein expression were no significantly correlated with that of breast cancer staging,age,molecular typing,HER-2 and axillary lymph node status.but The strong expression of Fas,FasL protein were significantly correlated with that of the axillary lymph node status and the expression of ki-67.Conclusion:The strong expression of Fas,FasL protein may be associated with breast cancer metastasis and progress,and they could be as indicators of the evaluation of prognosis of breast cancer.
