Impact of smoking on young acute coronary syndrome patients evaluated by optical coherence tomography
10.3969/j.issn.1004-8812.2018.05.001
- VernacularTitle:光学相干断层成像下吸烟对年轻急性冠状动脉综合征患者斑块特征的影响
- Author:
Wei LIU
1
;
Ya-Nan GAO
;
Fang-Jie HOU
;
Si-Jing WU
;
Yong-He GUO
;
Xiao-Li LIU
;
Hai-Long GE
;
Ying-Xin ZHAO
;
Yu-Jie ZHOU
Author Information
1. 首都医科大学附属北京安贞医院心内科 北京市心肺血管疾病研究所
- Keywords:
Smoking;
Coronary atherosclerotic plaque;
Optical coherence tomography
- From:
Chinese Journal of Interventional Cardiology
2018;26(5):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of smoking on coronary plaque characteristics on optical coherence tomography(OCT) in young patients with acute coronary disease(ACS).Methods We assessed the atherosclerotic plaque characteristics and vulnerability by OCT and coronary angiography in 60 ACS patients aged 45 years or younger in Beijing Anzhen Hospital, from June 2014 to June 2017. The patients were divided into the smoking group(n=33) and the non-smoking group(n=27) to compare the plaque characteristics and vulnerability.Results Smoking patients showed a less extent of fibrosis(48.55％vs. 77.8％,P=0.032)and microchannels(18.2％vs. 44.4％,P=0.033), and a greater extent of plaque rupture (24.2％vs. 3.7％,P=0.033) compared with non-smoking patients. In multivariate analysis, smoking was the only independent predictors of plaque rupture(OR 8.320, 95％CI 0.969-71.435,P=0.027) and less fibrosis (OR 0.269, 95％CI 0.086-0.837,P=0.020). Conclusions Patients who are smokers have less extensive fibrosis and a greater extent of plaque rupture, showing more extensive vulnerable plaque phenotype. Therefore, smoking is one of the major risk factors of advanced cardiovascular events in young patients.
