Eff ect of early intervention on 12-month follow-up clinical prognosis in patients with high-risk non-ST-segment elevation acute coronary syndrome
10.3969/j.issn.1004-8812.2018.01.006
- VernacularTitle:早期介入治疗对高危非ST段抬高型急性冠状动脉综合征患者12个月临床结果的影响
- Author:
Cheng-Yi XU
1
;
Xin-Tian LIU
;
Cheng-Wei LIU
;
Ming-Xiang WU
;
Xi SU
;
Jian PENG
;
Dan SONG
;
Min WANG
;
Hua YAN
;
Jian-Hua CAI
Author Information
1. 武汉亚洲心脏病医院心内科
- Keywords:
Early invasive strategy;
Non ST-segment elevation acute coronary syndrome;
High-risk
- From:
Chinese Journal of Interventional Cardiology
2018;26(1):24-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare 12-month follow-up clinical outcome of an early to a delayed intervention in the management of high-risk non-ST elevation acute coronary syndrome (NSTE-ACS) patients. Methods 758 consecutive high-risk NSTE-ACS patients treated with percutaneous coronary artery intervention(PCI)were enrolled between Jauary 2015 and December 2015 in Wuhan Asia Heart Hospital. They were divided into 2 groups according to diff erent intervention time, the early PCI group(within 24 h after diagnosis,n=185)and the delayed group (more than 24 h after diagnosis, n=573).The baseline clinical data, angiographic features, data related to PCI, the 12-month follow-up major adverse cardiac events (MACE) were analyzed retrospectively. MACE were defi ned as all-cause death and recurrent nonfatal myocardial infarction. Results Primary endpoint status after 12-month follow-up were collected in 711 of 758 initially enrolled patients. Incidence of MACE was 14.5% in the early and 11.2% in the delayed PCI group(χ2=1.289,P=0.256). No signifi cant diff erences were found in the occurrence of the individual components of all-cause death and nonfatal myocardial infarction. Mean hospital stay were(7.6±3.1)d in the early and (10.7±3.8)d in the delayed PCI group(t=2.489,P=0.014). Mean medical expenses in RMB were(48.5±13.5) thousand yuan in the early and(52.8±16.4)thousand yuan in the delayed PCI group(t=2.132,P=0.038). Conclusions After 12-month follow-up,no diff erence in incidence of MACE was seen between early and delayed invasive strategy,but with shorter hospital stay and reduced medical expenses.
